the effect of intratympanic dexamethasone with oral prednisolone as a primary treatment in idiopathic sudden sensorineural hearing loss
نویسندگان
چکیده
introduction: sudden sensorineural hearing loss (ssnhl) is a true emergency that must be diagnosed and treated immediately. the purpose of this study is to compare the efficacy of treatment with intratympanic dexamethasone plus oral prednisolone daily or every other day with that of treatment with oral prednisolone alone. materials and methods: sixty-three patients with ssnhl that had been present for less than 10 days prior to the start of treatment were randomly allocated to three different groups. patients in group a were treated daily with oral prednisolone 1 mg/kg for 10 days plus intratympanic dexamethasone 2 mg for the first 3 days of treatment. patients in group b were treated every other day with oral prednisolone 1 mg/kg for 10 days with the addition of intratympanic dexamethasone 2 mg for the first 3 treatments. patients in group c were treated daily with oral prednisolone 1 mg/kg alone for 10 days. audiometric parameters including pure tone audiometry (pta), speech reception threshold (srt), and speech discrimination score (sds) were assessed on days 1,5, and 10. results: there was a significant improvement in pta, srt and sds in each group over the 10 days but the greatest improvement was seen in the srt measurements of group a in comparison with group b (19.81 ± 2.15, p=0.04) and c (26.26 ± 0.08, p=0.01). the difference in srt between groups b and c was not statistically significant. conclusion: the administration of intratympanic dexamethasone 2 mg daily for 3 days has an additive effect to that of 10 days of oral prednisolone 1 mg/kg in the treatment of ssnhl.
منابع مشابه
The Effect of Intratympanic Dexamethasone with Oral Prednisolone as a Primary Treatment in Idiopathic Sudden Sensorineural Hearing Loss
Introduction: Sudden sensorineural hearing loss (SSNHL) is a true emergency that must be diagnosed and treated immediately. The purpose of this study is to compare the efficacy of treatment with intratympanic dexamethasone plus oral prednisolone daily or every other day with that of treatment with oral prednisolone alone. Materials and Methods: Sixty-three patients with SSNHL that had been p...
متن کاملThe Effect of Intratympanic Dexamethasone with Oral Prednisolone as a Primary Treatment in Idiopathic Sudden Sensorineural Hearing Loss
INTRODUCTION Sudden sensorineural hearing loss (SSNHL) is a true emergency that must be diagnosed and treated immediately. The purpose of this study is to compare the efficacy of treatment with intratympanic dexamethasone plus oral prednisolone daily or every other day with that of treatment with oral prednisolone alone. MATERIALS AND METHODS Sixty-three patients with SSNHL that had been pres...
متن کاملThe Role of High Dose Intratympanic Dexamethasone as Salvage Therapy for Idiopathic Sudden Sensorineural Hearing Loss.
OBJECTIVE The aim of this study was to assess the efficacy of a single high dose intratympanic (IT) dexamethasone (DEX) as salvage therapy for idiopathic sudden sensorineural hearing loss (ISSNHL) after unsuccessful treatment with oral corticosteroid (CS). MATERIALS AND METHODS This was a prospective open-label study of 59 patients treated with IT DEX after systemic CS therapy has failed. All...
متن کاملUse of Intratympanic Dexamethasone as a Salvage Treatment in Idiopathic Sudden Hearing Loss
Idiopathic sudden hearing loss (ISHL) is defined as a sensorineural hearing loss of 30 dB or more at least three contiguous frequencies, which develops over a period of a few hours to 72 hours . Its incidence is 520/100.000 or 4,000 new cases per one year . Almost 98% of the patients are affected unilaterally . Although viral infections, vascular disorders, rupture of cochlear membranes, immuno...
متن کاملIntratympanic injection of dexamethasone for treatment of tinnitus in patients with sudden sensorineural hearing loss
The purpose of this study is to test the effectiveness of intratympanic dexamethasone injections as a treatment for severe tinnitus in idiopathic sudden sensorineural hearing loss (SNHL). We studied 37 patients who received intratympanic dexamethasone injections and 14 control patients who did not receive it, with severe tinnitus after onset of unilateral sudden SNHL. Hearing level did not chan...
متن کاملOral steroid treatment for idiopathic sudden sensorineural hearing loss
ضارمأب ةباصلإا مدعو نسلا ةثادح نأ جئاتنلا ترهظأ :جئاتنلا ةيبلقلا ضارملأاو ،مدلا طغض عافتراو ،يركسلاك( ىرخأ ـب ةباصلإا نم مايأ ةعبس نوضغ يف جلاعلا يقّلتو )ةيئاعولا تاذ ةيعمس تاطيطخت دوجوو لدتعُحلما عمسلا نادقْفو ،ISSHL لضفأ ةقيرطب عمسلا ةداعتسا يف تمهاس ،ةدعاص تاءانحنا ةيقنلا ةمغنلا عمس سايق غلبو .ةيئاصحلإا ةيحانلا نم ريثكب ،طسوتلما يف لبيسيد 23.9 ± 67.8 رملأا لوأ يف )PTA( و لبيسيد 51.6±28.7 ىلإ ني...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of otorhinolaryngologyجلد ۲۴، شماره ۱، صفحات ۱۹-۲۲
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023